Pericardium

CardiovascularOrgansThorax

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What it is
A tough two-layered sac enclosing the heart and the roots of the great vessels: an outer fibrous layer fused to the diaphragm below and the great vessels above, lined by a serous layer that also covers the heart surface (epicardium).
Function
Anchors the heart in the mediastinum, limits sudden over-filling and lets the heart beat almost frictionlessly on a film of fluid.
Size
Wall ~1–2 mm thick; contains ~15–50 mL of serous fluid.
Clinical note
Fluid or blood accumulating in the sac can compress the heart (cardiac tamponade); inflammation (pericarditis) causes sharp chest pain eased by leaning forward.